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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-Olinone
Olinone

Chemical Structure : Olinone

CAS No.: 1770789-37-1

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Olinone

货号: PC-62475Not For Human Use, Lab Use Only.

Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM).
    Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation.

    物理化学性质&存储条件

    分子量 299.374
    分子式 C17H21N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[4-(1-Oxo-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-butyl]-acetamide

    参考文献

    1. Gacias M, et al. Chem Biol. 2014 Jul 17;21(7):841-54.

    2. Chiang CM. Chem Biol. 2014 Jul 17;21(7):804-6.

    3. Zhao L, et al. J Neuroinflammation. 2017 Jan 19;14(1):14.al.

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