Oliceridine (Olinvo, TRV130) | MOR agonist | Probechem Biochemicals

Chemical Structure : Oliceridine

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Oliceridine (Olinvo, TRV130, TRV-130)

货号: PC-61681Not For Human Use, Lab Use Only.

Oliceridine (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.

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Oliceridine (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.
Oliceridine displays 178-fold selectivity over KOR and 355-fold selectivity over DOR.
Oliceridine elicits robust G protein signaling, with potency and efficacy similar to morphine in cell-based assays.
Oliceridine is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine in mice and rats.

物理化学性质&存储条件

分子量	386.55
分子式	C22H30N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((3-methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamine

参考文献

1. Chen XT, et al. J Med Chem. 2013 Oct 24;56(20):8019-31.

2. DeWire SM, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17.

3. Schneider S, et al. Biochemistry. 2016 Nov 22;55(46):6456-6466.

Oliceridine (Olinvo, TRV130, TRV-130)

生物&药学活性

物理化学性质&存储条件

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Oliceridine (Olinvo, TRV130, TRV-130)

生物&药学活性

物理化学性质&存储条件

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