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Ogremorphin

Chemical Structure : Ogremorphin

CAS No.: 294648-66-1

Ogremorphin (OGM8345, OGM)

货号: PC-49417Not For Human Use, Lab Use Only.

Ogremorphin (OGM, OGM8345) is a highly specific, first-in-class small-molecule inhibitor of GPR68 with IC50 of 0.71 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Ogremorphin (OGM, OGM8345) is a highly specific, first-in-class small-molecule inhibitor of GPR68 with IC50 of 0.71 uM, also inhibits ADAMTS-5.
    Ogremorphin (OGM1, OGM8345) was discovered in a chemical genetic zebrafish screen for its ability to perturb neural crest development, which shares basic cell behaviors of migration and invasion with cancer metastasis.
    Ogremorphin also inhibited migration and invasive behavior of neural crest–derived human melanoma cells in vitro.

    物理化学性质&存储条件

    分子量 309.387
    分子式 C17H15N3OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-ethyl-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one

    参考文献

    1. Charles H Williams, et al. Exp Hematol Oncol. 2024 Jan 31;13(1):13.

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