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首页-小分子抑制剂&激动剂-GPCR-Proton-sensing GPCRs-Ogerin
Ogerin

Chemical Structure : Ogerin

CAS No.: 1309198-71-7

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Ogerin (ZINC 67740571)

货号: PC-61084Not For Human Use, Lab Use Only.

Ogerin (ZINC 67740571) is a selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65.

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10 mg ￥1380 In stock
25 mg ￥2480 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ogerin (ZINC 67740571) is a selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65.
Ogerin only shows moderate affinity at 5-HT2B and the A2A receptor in a panel of 58 GPCRs.
Ogerin attenuates contextual-based fear memory without effects on cue-based memory in mice.

物理化学性质&存储条件

分子量 307.35
分子式 C17H17N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol

参考文献

1. Huang XP, et al. Nature. 2015 Nov 26;527(7579):477-83.

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