Oclacitinib (PF-03394197) | JAK inhibitor | Probechem Biochemicals

Chemical Structure : Oclacitinib

CAS No.: 1208319-26-9

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Oclacitinib (PF-03394197 freebase, APOQUEL)

货号: PC-22617Not For Human Use, Lab Use Only.

Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
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生物&药学活性

Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Oclacitinib (PF-03394197) does not significantly inhibit a panel of 38 other kinases when tested at 1 uM.
Oclacitinib (PF-03394197) inhibits IL-2, IL-4, IL-6, IL-13, and IL-31 with IC50's ranging from 36 to 249 nM, much less potent against erythropoietin and GM-CSF.
Oclacitinib (PF-03394197) inhibited JAK1-dependent cytokine receptor complexes involved in inflammation and pruritus, common clinical signs in canine allergic skin disease.

物理化学性质&存储条件

分子量	337.44
分子式	C15H23N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide

参考文献

1. Fukuyama T, et al. Eur J Pharmacol. 2017 Jan 5;794:20-26.

2. Panteri A, et al. Vet Dermatol. 2016 Feb;27(1):22-e7.

3. Gonzales AJ, et al. J Vet Pharmacol Ther. 2014 Aug;37(4):317-24.

Oclacitinib (PF-03394197 freebase, APOQUEL)

生物&药学活性

物理化学性质&存储条件

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Oclacitinib (PF-03394197 freebase, APOQUEL)

生物&药学活性

物理化学性质&存储条件

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