Ociperlimab | Anti-TIGIT mAb | Probechem Biochemicals

Chemical Structure : Ociperlimab

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Ociperlimab (BGB-A1217)

货号: PC-38834Not For Human Use, Lab Use Only.

Ociperlimab (BGB-A1217) is a novel humanized IgG1 anti-TIGIT antibody (mAb) with anti-tumor activities.

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生物&药学活性

Ociperlimab (BGB-A1217) is a novel humanized IgG1 anti-TIGIT antibody (mAb) with anti-tumor activities.
BGB-A1217 binds to the extracellular domain of human TIGIT with high affinity (KD=0.135 nM) and specificity, and efficiently blocks the interaction between TIGIT and its ligands PVR or PVR-L2.
BGB-A1217 significantly enhances T-cell functions in cell-based assays.
BGB-A1217 induces antibody dependent cellular cytotoxicity (ADCC) against Treg cells, activates NK cells and monocytes, and removes TIGIT from T cell surfaces in an Fc-dependent manner.
BGB-A1217, either alone or in combination with an anti-PD-1 mAb elicits strong immune responses and potent anti-tumor efficacy in pre-clinical models.

Isotype: IgG1-kappa.

Anti-[human TIGIT (T-cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane
member 3, VSTM3)], humanized monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Xin Chen, et al. Front Immunol. 2022 Feb 22;13:828319.

Ociperlimab (BGB-A1217)

生物&药学活性

物理化学性质&存储条件

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Ociperlimab (BGB-A1217)

生物&药学活性

物理化学性质&存储条件

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