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首页-抗体和重组蛋白-Biosimilar Antibody-Obinutuzumab
Obinutuzumab

Chemical Structure : Obinutuzumab

CAS No.: 949142-50-1

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Obinutuzumab (GA101, Anti-Human CD20 type II, Humanized Antibody)

货号: PC-26993Not For Human Use, Lab Use Only.

Obinutuzumab (GA101, GA-101) is a third-generation, humanized and glyco-engineered anti-CD20 mAb, binds with high affinity to the CD20 type II epitope, resulting in the induction of antibody-dependent cytotoxicity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Obinutuzumab (GA101, GA-101) is a third-generation, humanized and glyco-engineered anti-CD20 mAb, binds with high affinity to the CD20 type II epitope, resulting in the induction of antibody-dependent cytotoxicity.
Obinutuzumab also exhibits superior direct cell killing properties than rituximab.
Obinutuzumab induced dose-dependent antitumor activity, complete tumor regression and improved long-term survival in xenograft mouse models of B-cell malignancy.
Isotype: Human IgG1 kappa

物理化学性质&存储条件

分子量 146.32 kDa
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Human IgG1 kappa

参考文献

1. Mössner E, et al. Blood. 2010 Jun 3;115(22):4393-402.

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