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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-OXM2
OXM2

Chemical Structure : OXM2

CAS No.:

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OXM2 (CCR6 antagonist)

货号: PC-23013Not For Human Use, Lab Use Only.

OXM2 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.78.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OXM2 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.78.
OXM2 is not active against other chemokine receptors (CKRs).

物理化学性质&存储条件

分子量 408.42
分子式 C21H23F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-((4-(bicyclo[1.1.1]pentan-1-yl)-5-oxomorpholin-2-yl)methyl)-1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

参考文献

1. Wasilko DJ, et al. Nat Commun. 2024 Aug 31;15(1):7574.

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