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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-OXM1
OXM1

Chemical Structure : OXM1

CAS No.:

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OXM1 (CCR6 antagonist)

货号: PC-23012Not For Human Use, Lab Use Only.

OXM1 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.8.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OXM1 is a highly selective, allosteric antagonist of CCR6, inhibits CCL20-mediated CCR6+ human T-cell chemotaxis with pIC50 of 6.8.
OXM1 is not active against other chemokine receptors (CKRs).

物理化学性质&存储条件

分子量 424.93
分子式 C24H25ClN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(4-chlorophenyl)-N-((4-(2,3-dihydro-1H-inden-2-yl)-5-oxomorpholin-2-yl)methyl)cyclopropane-1-carboxamide

参考文献

1. Wasilko DJ, et al. Nat Commun. 2024 Aug 31;15(1):7574.

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