OX04529 | GPR84 agonist | Probechem Biochemicals

Chemical Structure : OX04529

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OX04529 (OX 04529)

货号: PC-21648Not For Human Use, Lab Use Only.

OX04529 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 18.5 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.

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生物&药学活性

OX04529 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 18.5 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
OX04529 does not show β-arrestin-2 recruitment activity in CHO-β-arrestin-hGPR84 cells (EC50>80 uM).
OX04529 also displays no activity at FFA1, FFA4, and CB2.
OX04529 does not show evidence of cytotoxicity after a 20 h incubation up to 30 uM in CHO-hGPR84 cells and CHO-K1 cells.

物理化学性质&存储条件

分子量	331.72
分子式	C15H13ClF3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(4-Chloro-3-(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine 1-oxide

参考文献

1. Pinqi Wang, et al. J Med Chem. 2023 Dec 26. doi: 10.1021/acs.jmedchem.3c00951.

OX04529 (OX 04529)

生物&药学活性

物理化学性质&存储条件

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OX04529 (OX 04529)

生物&药学活性

物理化学性质&存储条件

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