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首页-小分子抑制剂&激动剂-GPCR-GPR84-OX04528
OX04528

Chemical Structure : OX04528

CAS No.: 3028055-45-7

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OX04528 (OX 04528, OX-04528)

货号: PC-21647Not For Human Use, Lab Use Only.

OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.

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5 mg ￥2980 In stock
10 mg ￥4580 In stock
25 mg ￥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
OX04528 does not show β-arrestin-2 recruitment activity in CHO-β-arrestin-hGPR84 cells (EC50>80 uM).
OX04528 also displays no activity at FFA1, FFA4, and CB2.
OX04528 does not show evidence of cytotoxicity after a 20 h incubation up to 30 uM in CHO-hGPR84 cells and CHO-K1 cells.

物理化学性质&存储条件

分子量 365.28
分子式 C16H13F6NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-(3,5-Bis(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine 1-oxide

参考文献

1. Pinqi Wang, et al. J Med Chem. 2023 Dec 26. doi: 10.1021/acs.jmedchem.3c00951.

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