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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-Pim-OX01401
OX01401

Chemical Structure : OX01401

CAS No.: 1445692-05-6

OX01401 (OX-01401, OX1401)

货号: PC-72350Not For Human Use, Lab Use Only.

OX01401 (OX-01401, OX1401) is a potent, selective and cell active inhibitor of the PIM kinase family (PIM1 IC50=15.1 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    OX01401 (OX-01401, OX1401) is a potent, selective and cell active inhibitor of the PIM kinase family (PIM1 IC50=15.1 nM).
    OX01401 inhibited proliferation of two PIM-expressing leukaemic cancer cell lines, MV4-11 (IC50=0.5 uM) and PC3 cell (IC50=1.1 uM), and to reduced intracellular phosphorylated 4EBP1 protein in a concentration dependent manner.

    物理化学性质&存储条件

    分子量 401.499
    分子式 C19H19N3O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-2-(((1-(hydroxymethyl)cyclobutyl)methyl)amino)-5-((2-(2-hydroxyphenyl)thiazol-4-yl)methylene)thiazol-4(5H)-one

    参考文献

    1. Camilo E Quevedo, et al. Bioorg Med Chem. 2020 Nov 15;28(22):115724.

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