OV350 | KCC2 activator | Probechem Biochemicals

Chemical Structure : OV350

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OV350 (OV 350, OV-350)

货号: PC-21203Not For Human Use, Lab Use Only.

OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.

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生物&药学活性

OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.
OV350 reduces neuronal Cl− accumulation and slows the development of seizure-like events in brain slices, limits neuronal hyperexcitability.
OV350 prevents the development of BDZ-RSE, restores the efficacy of Diazepam (DZ) to terminate ongoing BDZ-RSE, reduces neuronal cell death 48 h after BDZ-RSE.

物理化学性质&存储条件

分子量	605.74
分子式	C35H39N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(4'-{2-[3-(but-3- yn-1-yl)-3H-diaziren- 3-yl]ethoxy}[1,1'- biphenyl]-4- yl)amino]-2-(2- cyclopropyl- morpholin-4-yl)-6- (propan-2-yl)-5,6- dihydro-7H- pyrrolo[3,4- d]pyrimidin-7-one

参考文献

1. Rebecca Jarvis, et al. Cell Rep Med. 2023 Mar 21;4(3):100957.

2. Patent WO2021180952A1.

OV350 (OV 350, OV-350)

生物&药学活性

物理化学性质&存储条件

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OV350 (OV 350, OV-350)

生物&药学活性

物理化学性质&存储条件

参考文献

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