OV329 | GABA-AT inhibitor | Probechem Biochemicals

Chemical Structure : OV329

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OV329 (OV 329)

货号: PC-49815Not For Human Use, Lab Use Only.

OV329 (OV 329) is a highly potent inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) with Ki of 9.69 uM.

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生物&药学活性

OV329 (OV 329) is a highly potent inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) with Ki of 9.69 uM.
OV329 is 10 times more potent as an inactivator of GABA-AT than CPP-115, OV329 has favorable pharmacokinetic properties and low off-target activities.
OV329 (5-40 mg/kg, i.p.) dose-dependently increases the thresholds of intravenous pentylenetetrazole (ivPTZ)-induced seizures.
OV329 is dramatically superior to CPP-115 in suppressing the release of dopamine in the corpus striatum, which occurs subsequent to either an acute cocaine or nicotine challenge in vivo.
OV329 also attenuates increased metabolic demands (neuronal glucose metabolism) in the hippocampus, a brain region that encodes spatial information concerning the environment in which an animal receives a reinforcing or aversive drug.

物理化学性质&存储条件

分子量	175.13
分子式	C7H7F2NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-amino-4-(difluoromethylene)cyclopent-1-ene-1-carboxylic acid

参考文献

1. Moschitto MJ, et al. Org Lett. 2018 Aug 3;20(15):4589-4592.

2. Feja M, et al. Epilepsia. 2021 Dec;62(12):3091-3104.

3. Juncosa JI, et al. J Am Chem Soc. 2018. February 14;140:2151–2164.

OV329 (OV 329)

生物&药学活性

物理化学性质&存储条件

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OV329 (OV 329)

生物&药学活性

物理化学性质&存储条件

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