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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-OUL35
OUL35

Chemical Structure : OUL35

CAS No.: 6336-34-1

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OUL35 (OUL 35;OUL-35;NSC39047)

货号: PC-35378Not For Human Use, Lab Use Only.

OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family.
OUL35 rescues cells from ARTD10 induced cell death, sensitizes cancer cells to the hydroxyurea-induced genotoxic stress.
OUL35 is a cell biology tool compound for selective inhibition of ARTD10-mediated MARylation and investigation of ARTD10 in DNA-damage repair.

物理化学性质&存储条件

分子量 256.261
分子式 C14H12N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-Carbamoylphenoxy)benzamide

参考文献

1. Venkannagari H, et al. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260.

2. Murthy S, et al. Eur J Med Chem. 2018 Jun 20;156:93-102.

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