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首页-小分子抑制剂&激动剂-Others-Other Targets-OU749
OU749

Chemical Structure : OU749

CAS No.: 519170-13-9

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OU749 (OU-749)

货号: PC-22154Not For Human Use, Lab Use Only.

OU749 is a potent, species-specific inhibitor of human gamma-glutamyl transpeptidase (GGT) with Ki of 17.6 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

OU749 is a potent, species-specific inhibitor of human gamma-glutamyl transpeptidase (GGT) with Ki of 17.6 uM.
OU749 is a competitive inhibitor of the acceptor glycyl-glycine, occupies the acceptor site while binding to the gamma-glutamyl substrate complex.
OU749 is more than 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells.
OU749 is species-specific, inhibiting GGT isolated from human kidney with 7-10-fold greater potency than GGT isolated from rat or mouse kidney.
OU749 does not inhibit GGT from pig cells.

物理化学性质&存储条件

分子量 361.43
分子式 C16H15N3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[5-[(4-Methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide

参考文献

1. King JB, et al. J Biol Chem. 2009 Apr 3;284(14):9059-65.

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