OTS193320 |CAS:2093401-33-1 Probechem Biochemicals

Chemical Structure : OTS193320

CAS No.: 2093401-33-1

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OTS193320 (OTS-193320;OTS 193320)

货号: PC-35633Not For Human Use, Lab Use Only.

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
OTS193320 significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death.
OTS193320 attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent.
OTS193320 causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM.

物理化学性质&存储条件

分子量	536.029
分子式	C28H30ClN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1s,4s)-N1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N4-(4-nitrobenzyl)cyclohexane-1,4-diamine

参考文献

1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.

OTS193320 (OTS-193320;OTS 193320)

生物&药学活性

物理化学性质&存储条件

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OTS193320 (OTS-193320;OTS 193320)

生物&药学活性

物理化学性质&存储条件

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