OTS186935 |CAS:2093400-18-9 Probechem Biochemicals

Chemical Structure : OTS186935

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OTS186935 (OTS-186935;OTS 186935)

货号: PC-35634Not For Human Use, Lab Use Only.

OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.

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生物&药学活性

OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.
OTS186935 causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%.
OTS186935 attenuates the levels of H3K9me3 in A549 xenograft mouse model.

物理化学性质&存储条件

分子量	463.966
分子式	C25H26ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N-(pyridin-4-ylmethyl)pyrrolidin-3-amine

参考文献

1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.

OTS186935 (OTS-186935;OTS 186935)

生物&药学活性

物理化学性质&存储条件

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OTS186935 (OTS-186935;OTS 186935)

生物&药学活性

物理化学性质&存储条件

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