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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-OTB-658
OTB-658

Chemical Structure : OTB-658

CAS No.: 2245791-50-6

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OTB-658 (OTB658)

货号: PC-20081Not For Human Use, Lab Use Only.

OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.
    OTB-658 exhibits potent activity against M. tuberculosis H37Rv in the early stage of infection.
    OTB-658 has MIC value of 0.080 to 0.115 μg/ml against M. tuberculosis H37Rv.
    OTB-658 is active against 10 drug-susceptible and 30 drug-resistant clinical isolates and is as potent as Linezolid and PNU-100480 (Sutezolid).
    OTB-658 achieves bacteriostatic effect against M. tuberculosis at the MIC to 32× MIC (MBC).
    OTB-658 (25 mg/kg) demonstrates better bacteriostatic activity in the early stage of infection in acute murine models, compared with Linezolid (50 mg/kg). OTB-658 shows no cross-resistance with Isoniazid (INH) and Rifampin (RIF).

    物理化学性质&存储条件

    分子量 381.42
    分子式 C17H20FN3O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(((3S,3aS)-8-fluoro-1-oxo-7-thiomorpholino-3a,4-dihydro-1H,3H-benzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methyl)acetamide

    参考文献

    1. Guo S, et al. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0097421.

    2. Liu H, et al. Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0139922.

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