OT-82 | NAMPT inhibitor | Probechem Biochemicals

Chemical Structure : OT-82

CAS No.: 1800487-55-1

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OT-82 (NAMPT inhibitor OT-82)

货号: PC-38153Not For Human Use, Lab Use Only.

OT-82 (NAMPT inhibitor OT-82) is a novel selective and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), reduces the viability of leukemia cells with IC50 of 0.2-4 nM.

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10 mg	￥3480	In stock
25 mg	￥5580	In stock
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生物&药学活性

OT-82 (NAMPT inhibitor OT-82) is a novel selective and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), reduces the viability of leukemia cells with IC50 of 0.2-4 nM.
Similar to the leukemia cell lines, the PDX cells were highly sensitive to OT-82 treatment with IC50 values ranging from 0.4 to 3.6 nM.
OT-82 exerts its antileukemic action by reducing cellular NAD+ and inducing apoptosis.
OT-82 induces significant leukemia regression in vivo in a large panel of ALL PDXs derived from high-risk and poor outcome pediatric patients.

物理化学性质&存储条件

分子量	424.479
分子式	C26H21FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1H-pyrazol-4-yl)propyl)-3-((4-fluorophenyl)ethynyl)-4-(pyridin-4-yl)benzamide

参考文献

1. Teicher B, et al. Leukemia. 2020 Jun;34(6):1524-1539.

2. Korotchkina L, et al. Leukemia. 2020 Jul;34(7):1828-1839.

OT-82 (NAMPT inhibitor OT-82)

生物&药学活性

物理化学性质&存储条件

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OT-82 (NAMPT inhibitor OT-82)

生物&药学活性

物理化学性质&存储条件

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