OSU-T315 | ILK inhibitor | Probechem Biochemicals

Chemical Structure : OSU-T315

CAS No.: 1333146-24-9

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OSU-T315 (OSU-T 315)

货号: PC-45519Not For Human Use, Lab Use Only.

OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
OSU-T315 exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells.
OSU-T315 facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain.
OSU-T315 suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis.
OSU-T315 demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.

物理化学性质&存储条件

分子量	533.5873
分子式	C30H30F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-

参考文献

1. Lee SL, et al. J Med Chem. 2011 Sep 22;54(18):6364-74.

2. Liu TM, et al. Blood. 2015 Jan 8;125(2):284-95.

OSU-T315 (OSU-T 315)

生物&药学活性

物理化学性质&存储条件

参考文献

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OSU-T315 (OSU-T 315)

生物&药学活性

物理化学性质&存储条件

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