OSSL_325096 | p97/VCP inhibitor | Probechem Biochemicals

Chemical Structure : OSSL_325096

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OSSL_325096 (OSSL-325096)

货号: PC-38720Not For Human Use, Lab Use Only.

OSSL_325096 is a novel potent small mlolecule p97/VCP inhibitor, suppresses cell proliferation and induces ER stress and apoptotic cell death in MM cell lines (IC50=0.1-0.5 uM).

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生物&药学活性

OSSL_325096 is a novel potent small mlolecule p97/VCP inhibitor, suppresses cell proliferation and induces ER stress and apoptotic cell death in MM cell lines (IC50=0.1-0.5 uM).
OSSL_325096 induces apoptosis in bortezomib‐resistant multiple myeloma (MM) cells and primary MM cells from two bortezomib‐refractory patients but not in PBMC from a healthy donor.
OSSL_325096 inhibits ATPase activity in vitro, downregulates BCL2 and upregulated cell cycle and heat shock‐related proteins.
OSSL_325096 suppressed multiple myeloma (MM) cell proliferation in vivo without lethal toxicity.

物理化学性质&存储条件

分子量	397.482
分子式	C24H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((4-((1-phenylethyl)amino)quinazolin-2-yl)amino)phenyl)acetamide

参考文献

1. Nao Nishimura, et al. Cancer Sci. 2019 Oct;110(10):3275-3287.

OSSL_325096 (OSSL-325096)

生物&药学活性

物理化学性质&存储条件

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OSSL_325096 (OSSL-325096)

生物&药学活性

物理化学性质&存储条件

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