OSMI-4 | O-GlcNAc transferase inhibitor | Probechem Biochemicals

Chemical Structure : OSMI-4

CAS No.: 2260791-14-6

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OSMI-4 (OGT inhibitor 4b)

货号: PC-35723Not For Human Use, Lab Use Only.

OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM.

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2 mg	￥2480	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
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生物&药学活性

OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM.
OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM (O-GlcNAc (RL-2) blot of HEK293T cell lysates after treatment).
OSMI-4 is the best OGT inhibitor reported to date, and it is especially attractive for probing OGT’s complex biology.

物理化学性质&存储条件

分子量	604.089
分子式	C27H26ClN3O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

参考文献

1. Martin SES, et al. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.

OSMI-4 (OGT inhibitor 4b)

生物&药学活性

物理化学性质&存储条件

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OSMI-4 (OGT inhibitor 4b)

生物&药学活性

物理化学性质&存储条件

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