OSI-930 |CAS:728033-96-3 Probechem Biochemicals

Chemical Structure : OSI-930

CAS No.: 728033-96-3

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OSI-930 (OSI 930;OSI930)

货号: PC-42449Not For Human Use, Lab Use Only.

A potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15 nM and 9 nM, respectively.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

OSI-930 is a potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15 nM and 9 nM, respectively.
OSI-930 also inhibits Lck, c-Raf, Flt1, and CSF-1R (IC50<100 nM).
OSI-930 exhibits antitumor activity in mutant Kit-expressing HMC-1 xenograft model.

物理化学性质&存储条件

分子量	443.4416
分子式	C22H16F3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxamide, 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-

参考文献

1. Garton AJ, et al. Cancer Res. 2006 Jan 15;66(2):1015-24.

2. Yap TA, et al. Clin Cancer Res. 2013 Feb 15;19(4):909-19.

3. Patel JP, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6495-9.

4. Macpherson IR, et al. Eur J Cancer. 2013 Mar;49(4):782-9.

OSI-930 (OSI 930;OSI930)

生物&药学活性

物理化学性质&存储条件

参考文献

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OSI-930 (OSI 930;OSI930)

生物&药学活性

物理化学性质&存储条件

参考文献

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