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首页-小分子抑制剂&激动剂-Tyrosine Kinase-c-Met (HGFR)-OSI-296
OSI-296

Chemical Structure : OSI-296

CAS No.: 1175296-94-2

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OSI-296 (OSI 296)

货号: PC-49517Not For Human Use, Lab Use Only.

OSI-296 is a potent and selective inhibitor of c-MET and RON kinases with cellular IC50 of 42 and 200 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    OSI-296 is a potent and selective inhibitor of c-MET and RON kinases with cellular IC50 of 42 and 200 nM, respectively.
    OSI-296 shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated.

    物理化学性质&存储条件

    分子量 465.31
    分子式 C21H19Cl2FN4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(6-amino-7-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)furo[3,2-c]pyridin-3-yl)-3,6-dihydropyridine-1(2H)-carboxamide

    参考文献

    1. Arno G Steinig, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4381-7.

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