OSBPL7 inhibitor Cpd G | ABCA1 inducer, OSBPL7 inhibitor

Chemical Structure : OSBPL7 inhibitor Cpd G

CAS No.: 1269826-44-9

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OSBPL7 inhibitor Cpd G (ABCA1 inducer Cpd G)

货号: PC-72587Not For Human Use, Lab Use Only.

ABCA1 inducer Cpd G (Cpd G) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ABCA1 inducer Cpd G (Cpd G) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).
Cpd G displays little to no binding affinity to the CB1R (Ki>1 uM).
Cpd G increases plasma membrane ABCA1 in cultured human podocytes, and significantly increases ABCA1-dependent cholesterol efflux at 10 uM.
Cpd G significantly increased apoAI-mediated cholesterol efflux at 10 uM.
Cpd G (100 mg/Kg) protects from kidney injury in a mouse model of adriamycin-induced nephropathy.
Cpd G protects from renal injury in the mouse model of Alport syndrome.
Cpd G reduced accumulation of cholesterol esters in renal cortex in both disease models.

物理化学性质&存储条件

分子量	463.278
分子式	C20H19Cl2F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

参考文献

1. Matthew B Wright, et al. Nat Commun. 2021 Aug 2;12(1):4662.

OSBPL7 inhibitor Cpd G (ABCA1 inducer Cpd G)

生物&药学活性

物理化学性质&存储条件

参考文献

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OSBPL7 inhibitor Cpd G (ABCA1 inducer Cpd G)

生物&药学活性

物理化学性质&存储条件

参考文献

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