ORM-10962 | NCX inhibitor | Probechem Biochemicals

Chemical Structure : ORM-10962

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ORM-10962 (ORM10962)

货号: PC-63232Not For Human Use, Lab Use Only.

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, significantly reduces inward/outward NCX currents with IC50 of 55 and 67 nM, respectively.

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生物&药学活性

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, significantly reduces inward/outward NCX currents with IC50 of 55 and 67 nM, respectively。
ORM-10962 does not modify significantly the magnitude of ICaL in cardiac myocytes, as well as the inward rectifier, transient outward, IKs, the late and peak sodium and Na+/K+ pump currents。
ORM-10962 can exert positive as well as negative inotropic effect depending on the actual operation mode of NCX.

物理化学性质&存储条件

分子量	459.546
分子式	C27H29N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-hydroxy-piperidin-1-yl)-N-(6-((2-phenylchroman-6yl)oxy)pyridin-3-yl)acetamide

参考文献

1. Kohajda Z, et al. PLoS One. 2016 Nov 10;11(11):e0166041.

2. Oravecz K, et al. Eur J Pharmacol. 2018 Jan 5;818:278-286.

ORM-10962 (ORM10962)

生物&药学活性

物理化学性质&存储条件

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ORM-10962 (ORM10962)

生物&药学活性

物理化学性质&存储条件

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