OR486 | COMT inhibitor | Probechem Biochemicals

Chemical Structure : OR486

CAS No.: 7659-29-2

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OR486 (OR-486, 3,5-Dinitrocatechol)

货号: PC-23347Not For Human Use, Lab Use Only.

OR486 (3,5-Dinitrocatechol, OR-486) is a potent, selective catechol-O-methyltransferase (COMT) inhibitor with IC50 of 12 nM.

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生物&药学活性

OR486 (3,5-Dinitrocatechol, OR-486) is a potent, selective catechol-O-methyltransferase (COMT) inhibitor with IC50 of 12 nM.
OR486 does not inhibit tyrosine hydroxylase, dopamine-beta-hydroxylase, dopa-decarboxylase and monoamine oxidase forms A and B.
OR486 is more effective in reducing the formation of 3-O-methyldopa from levodopa than was the levodopa-carbidopa treatment alone.

物理化学性质&存储条件

分子量	200.11
分子式	C6H4N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-Dinitrocatechol

参考文献

1. Nissinen E, et al. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9.

2. Werner P, et al. Brain Res. 2001 Mar 2;893(1-2):278-81.

OR486 (OR-486, 3,5-Dinitrocatechol)

生物&药学活性

物理化学性质&存储条件

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OR486 (OR-486, 3,5-Dinitrocatechol)

生物&药学活性

物理化学性质&存储条件

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