OR-S0 | EZH2 inhibitor | Probechem Biochemicals

首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-OR-S0

Chemical Structure : OR-S0

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OR-S0 (EZH2 inhibitor OR-S0)

货号: PC-72290Not For Human Use, Lab Use Only.

OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM).
OR-S0 inhibits H3K27me3 in HCT116 cells with IC50 of 24 nM, inhibited the growth of KARPAS‐422 cells in a dose‐dependent manner with GI50 of 210 nM.

物理化学性质&存储条件

分子量	616.763
分子式	C34H44N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-2,4-dimethyl-2-(morpholinomethyl)benzo[d][1,3]dioxole-5-carboxamide

参考文献

1. Daisuke Honma, et al. Cancer Sci. 2017 Oct;108(10):2069-2078.

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OR-S0 (EZH2 inhibitor OR-S0)

生物&药学活性

物理化学性质&存储条件

参考文献

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OR-S0 (EZH2 inhibitor OR-S0)

生物&药学活性

物理化学性质&存储条件

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