OPS-2071 | C. difficile inhibitor | Probechem Biochemicals

Chemical Structure : OPS-2071

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OPS-2071 (OPS2071)

货号: PC-22941Not For Human Use, Lab Use Only.

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生物&药学活性

OPS-2071 is a novel quinolone antibacterial agent with potent antibacterial activity against 54 clinically isolated C. difficile strains with MIC50 of 0.125 ug/mL, reduces the risk of adverse events typical of fluoroquinolone class antibiotics.
OPS-2071 is more active than vancomycin on a concentration basis (MIC50, 2 μg/ml; MIC90, 4 μg/ml) and comparable to fidaxomicin (MIC50, 0.063 μg/ml; MIC90, 8 μg/ml).
OPS-2071 shows equally potent antibacterial activity against both hypervirulent and nonhypervirulent strains.
OPS-2071 shows significant in vivo efficacy at 0.0313 mg/kg/day (50% effective doses), 39.0-fold and 52.1-fold lower than those of vancomycin and fidaxomicin, respectively, in a hamster model of C. difficile infection.

物理化学性质&存储条件

分子量	378.36
分子式	C20H15FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(6-amino-5-cyanopyridin-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

参考文献

1. Oka D, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e01170-20.

OPS-2071 (OPS2071)

生物&药学活性

物理化学性质&存储条件

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OPS-2071 (OPS2071)

生物&药学活性

物理化学性质&存储条件

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