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OPS-2071

Chemical Structure : OPS-2071

CAS No.: 1426216-93-4

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OPS-2071 (Abimufloxacin, OPS2071)

货号: PC-22941Not For Human Use, Lab Use Only.

Abimufloxacin (OPS-2071) is a novel quinolone antibacterial agent with potent antibacterial activity against 54 clinically isolated C. difficile strains with MIC50 of 0.125 ug/mL, reduces the risk of adverse events typical of fluoroquinolone class antibiotics.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Abimufloxacin (OPS-2071) is a novel quinolone antibacterial agent with potent antibacterial activity against 54 clinically isolated C. difficile strains with MIC50 of 0.125 ug/mL, reduces the risk of adverse events typical of fluoroquinolone class antibiotics.
    OPS-2071 is more active than vancomycin on a concentration basis (MIC50, 2 μg/ml; MIC90, 4 μg/ml) and comparable to fidaxomicin (MIC50, 0.063 μg/ml; MIC90, 8 μg/ml).
    OPS-2071 shows equally potent antibacterial activity against both hypervirulent and nonhypervirulent strains.
    OPS-2071 shows significant in vivo efficacy at 0.0313 mg/kg/day (50% effective doses), 39.0-fold and 52.1-fold lower than those of vancomycin and fidaxomicin, respectively, in a hamster model of C. difficile infection.

    物理化学性质&存储条件

    分子量 378.36
    分子式 C20H15FN4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(6-amino-5-cyanopyridin-3-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

    参考文献

    1. Oka D, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e01170-20.

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