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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-OPB-51602
OPB-51602

Chemical Structure : OPB-51602

CAS No.:

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OPB-51602 (OPB 51602;OPB51602)

货号: PC-70276Not For Human Use, Lab Use Only.

A novel small molecule SH2 domain-targeting STAT3 inhibitor with IC50/Kd of 7.3/5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A novel small molecule SH2 domain-targeting STAT3 inhibitor with IC50/Kd of 7.3/5 nM; does not bind to the S636A, V637A, and E638A SH2D mutants; effectively inhibits STAT3 phosphorylation (pTyr705 and pSer727) and cancer cell proliferation, impairs mitochondrial function; shows potent activity tumor xenografts in mice; orally bioactive.

Blood Cancer

Phase 1 Clinical

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Genini D, et al. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4924-E4933.

2. Wong AL, et al. Ann Oncol. 2015 May;26(5):998-1005.

3. Ogura M, et al. Cancer Sci. 2015 Jul;106(7):896-901.

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