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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-OPB-31121
OPB-31121

Chemical Structure : OPB-31121

CAS No.:

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OPB-31121 (OPB31121;OPB 31121)

货号: PC-70277Not For Human Use, Lab Use Only.

OPB-31121 (OPB31121) is a novel STAT3 inhibitor (IC50=18.7 nM, Kd=10 nM) that strongly inhibits STAT3 and STAT5 phosphorylation without upstream kinase inhibition.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OPB-31121 (OPB31121) is a novel STAT3 inhibitor (IC50=18.7 nM, Kd=10 nM) that strongly inhibits STAT3 and STAT5 phosphorylation without upstream kinase inhibition.
OPB-31121 induces significant growth inhibition in various hematopoietic malignant cells, particularly effective against multiple myeloma, Burkitt lymphoma and leukemia harboring BCR-ABL, FLT3/ITD and JAK2 V617F, oncokinases with their oncogenicities dependent on STAT3/5.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Brambilla L, et al. Mol Oncol. 2015 Jun;9(6):1194-206.

2. Hayakawa F, et la. Blood Cancer J. 2013 Nov 29;3:e166.

3. Genini D, et al. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4924-E4933.

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