OPB-111077 (OPB111077)

Chemical Structure : OPB-111077

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货号: PC-28758Not For Human Use, Lab Use Only.

OPB-111077 is a irst-in-class, orally available inhibitor of STAT3 and mitochondrial oxidative phosphorylation, inhibits mitochondrial respiratory chain Complex I, suppresses OXPHOS and exerts anti-tumour effects.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

OPB-111077 is a irst-in-class, orally available inhibitor of STAT3 and mitochondrial oxidative phosphorylation, inhibits mitochondrial respiratory chain Complex I, suppresses OXPHOS and exerts anti-tumour effects.

物理化学性质&存储条件

分子量	401.39
分子式	C21H18F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(2-methyl-4-(methylamino)phenoxy)pyridin-3-yl)-4-(trifluoromethyl)benzamide

参考文献

1. Tolcher A, et al. Oncologist. 2018 Jun;23(6):658-e72.

2. Takaki EO, et al. Br J Pharmacol. 2026 Nov 6. doi: 10.1111/bph.70719.