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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Glucocorticoid receptor (GR)-OP-3633
OP-3633

Chemical Structure : OP-3633

CAS No.: 2102494-14-2

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OP-3633 (OP3633)

货号: PC-72993Not For Human Use, Lab Use Only.

OP-3633 (OP3633) is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    OP-3633 (OP3633) is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM.
    OP-3633 demonstrated substantial inhibition of GR transcriptional activity in the GR positive HCC1806 triple negative breast cancer xenograft model.

    物理化学性质&存储条件

    分子量 445.647
    分子式 C30H39NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (8S,9R,10R,11S,13S,14S,17S)-11-(4-(Dimethylamino)-phenyl)-17-hydroxy-10,13-dimethyl-17-(prop-1-yn-1-yl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3Hcyclopenta[a]phenanthren-3-one

    参考文献

    1. Xiaohui Du, et al. J Med Chem. 2019 Jul 25;62(14):6751-6764

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