ONX 0801 (Idetrexed, CT900, BGC 945) | Antifolate | Probechem Biochemicals

Chemical Structure : ONX0801

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ONX0801 (Idetrexed, CT900, BGC 945)

货号: PC-49048Not For Human Use, Lab Use Only.

ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC).

物理化学性质&存储条件

分子量	647.641
分子式	C32H33N5O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]-benzoyl]-L-gamma-glutamyl-D-glutamic acid

参考文献

1. Tochowicz A, et al. J Med Chem. 2013 Jul 11;56(13):5446-55.

2. Gibbs DD, et al. Cancer Res. 2005 Dec 15;65(24):11721-8.