ONX-0914 (PR-957) | LMP7 inhibitor | Probechem Biochemicals

Chemical Structure : ONX-0914

CAS No.: 960374-59-8

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ONX-0914 (PR-957, ONX0914, PR957)

货号: PC-43393Not For Human Use, Lab Use Only.

ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2.
ONX-0914 (PR-957) blocks presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells.
ONX-0914 (PR-957) reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels in experimental arthritis models.

物理化学性质&存储条件

分子量	580.6719
分子式	C31H40N4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-

参考文献

1. Muchamuel T, et al. Nat Med. 2009 Jul;15(7):781-7.

2. Basler M, et al. J Immunol. 2010 Jul 1;185(1):634-41.

3. Ichikawa HT, et al. Arthritis Rheum. 2012 Feb;64(2):493-503.

4. Verbrugge SE, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):174-82.

ONX-0914 (PR-957, ONX0914, PR957)

生物&药学活性

物理化学性质&存储条件

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ONX-0914 (PR-957, ONX0914, PR957)

生物&药学活性

物理化学性质&存储条件

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