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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ONO-9517601
ONO-9517601

Chemical Structure : ONO-9517601

CAS No.: 2640753-22-4

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ONO-9517601 (VU6022856)

货号: PC-25625Not For Human Use, Lab Use Only.

ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.
ONO-9517601 shows no significant activity for TASK-1, TASK-2, THIK-1 and TRESK.
ONO-9517601 displayed robust efficacy in an MK-801 challenge rat NOR paradigm, with MED of 1 mg/kg.

物理化学性质&存储条件

分子量 461.95
分子式 C25H24ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1-Acetylpiperidin-4-yl)-4-chloro-N-(3-methyl-5-(phenylethynyl)pyridin-2-yl)-1H-pyrazole-5-carboxamide

参考文献

1. Tanaka M, et al. J Med Chem. 2025 Oct 17. doi: 10.1021/acs.jmedchem.5c02535.

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