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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Autotaxin-ONO-8430506
ONO-8430506

Chemical Structure : ONO-8430506

CAS No.: 1354805-08-5

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ONO-8430506 (ONO 8430506)

货号: PC-38743Not For Human Use, Lab Use Only.

ONO-8430506 is a highly potent, orally available autotaxin (ATX) inhibitor with IC50 of 10 nM (recombinant human ATX), exhibits LysoPLD inhibitory activity in human plasma with IC50 of 5.5 nM.

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1 mg ￥2480 In stock
5 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: 98.7% (HPLC) Select Batch:

生物&药学活性

ONO-8430506 is a highly potent, orally available autotaxin (ATX) inhibitor with IC50 of 10 nM (recombinant human ATX), exhibits LysoPLD inhibitory activity in human plasma with IC50 of 5.5 nM.
ONO-8430506 suppressed LPA formation in plasma and decreased rat intraurethral pressure in a dose-dependent manner。
ONO-8430506 enhances the antitumor effect of paclitaxel in breast cancer model.
ONO-8430506 (30 mg/kg) ameliorates neuropathic pain derived from lumbar spinal canal stenosis.

物理化学性质&存储条件

分子量 461.53
分子式 C27H28FN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[2-[9-[(4-Fluorophenyl)methyl]-5,6,8,9-tetrahydro-7H-pyrrolo[2,3-b:5,4-c′]dipyridin-7-yl]-2-oxoethyl]bicyclo[2.2.1]heptane-1-carboxylic acid

参考文献

1. Iwaki Y, et al. ACS Med Chem Lett. 2020 May 14;11(6):1335-1341.

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