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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-ONO-8055
ONO-8055

Chemical Structure : ONO-8055

CAS No.:

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ONO-8055 (ONO8055)

货号: PC-63165Not For Human Use, Lab Use Only.

ONO-8055 is a highly selective and potent EP2/EP3 dual agonist with EC50 of 0.67/0.7 nM, shows >450-fold selectivity over EP4 receptors (EC50=339 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ONO-8055 is a highly selective and potent EP2/EP3 dual agonist with EC50 of 0.67/0.7 nM, shows >450-fold selectivity over EP4 receptors (EC50=339 nM).
    ONO-8055 improves the lower urinary tract dysfunctions of neurogenic UAB in a rat lumber spinal canal stenosis model with twice-daily (bid) oral dosing of 0.01 mg/kg, demonstrates much higher in vivo efficacy than the currently used drug for UAB.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

    1. Kinoshita A, et al. Bioorg Med Chem. 2018 Jan 1;26(1):200-214.

    2. Sekido N, et al. J Urol. 2016 Aug;196(2):609-16.

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