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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ONO-7927846
ONO-7927846

Chemical Structure : ONO-7927846

CAS No.: 2640753-27-9

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ONO-7927846 (VU6024391)

货号: PC-25626Not For Human Use, Lab Use Only.

ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.
ONO-7927846 shows no significant activity for TASK-1, TASK-2, THIK-1 and TRESK.
ONO-7927846 displayed robust efficacy in an MK-801 challenge rat NOR paradigm, with MED of 0.3 mg/kg.

物理化学性质&存储条件

分子量 497.93
分子式 C25H22ClF2N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((3R,4R)-1-Acetyl-3-fluoropiperidin-4-yl)-4-chloro-N-(5-((4-fluorophenyl)ethynyl)-3-methylpyridin-2-yl)-1H-pyrazole-5-carboxamide

参考文献

1. Tanaka M, et al. J Med Chem. 2025 Oct 17. doi: 10.1021/acs.jmedchem.5c02535.

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