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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ONO-2920632
ONO-2920632

Chemical Structure : ONO-2920632

CAS No.: 2230296-66-7

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ONO-2920632 (VU6011887)

货号: PC-24079Not For Human Use, Lab Use Only.

ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%).
ONO-2920632 shows selectivity versus the other K2P channels (>91-fold selective vs TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selective vs TRESK) and no significant activity in a large ancillary pharmacology panel.
ONO-2920632 (VU6011887) displayed robust, dose dependent efficacy when dosed orally in a mouse pain model (acetic acid writhing assay).

物理化学性质&存储条件

分子量 354.26
分子式 C15H10F4N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-fluoro-4-(trifluoromethoxy)benzyl)-[1,2,4]triazolo[1,5-a]pyridine-6-carboxamide

参考文献

1. Yashiro K, et al. ACS Chem Neurosci. 2025 Feb 21. doi: 10.1021/acschemneuro.5c00032.

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