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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-OJI-1
OJI-1

Chemical Structure : OJI-1

CAS No.: 1620779-53-4

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OJI-1 (OJI1)

货号: PC-27743Not For Human Use, Lab Use Only.

OJI-1 is a potent, selective HDAC8 inhibitor with IC50 of 0.8 nM, mildly inhibits HDAC6 and HDAC1 with IC50s of 1.2 uM and 4.3 uM, does not inhibit other HDACs.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OJI-1 is a potent, selective HDAC8 inhibitor with IC50 of 0.8 nM, mildly inhibits HDAC6 and HDAC1 with IC50s of 1.2 uM and 4.3 uM, does not inhibit other HDACs.

物理化学性质&存储条件

分子量 372.43
分子式 C22H20N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

参考文献

1. Oscar J Ingham, et al. ACS Med Chem Lett. 2016 Sep 1;7(10):929-932.

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