OICR19451 | NUAK/MARK inhibitor | Probechem Biochemicals

Chemical Structure : OICR19451

加入收藏

OICR19451 (OICR-19451)

货号: PC-26480Not For Human Use, Lab Use Only.

OICR19451 is a potent and selective dual NUAK1/2 and MARK2/3 inhibitor with IC50 of 12/10 nM for NUAK1/NUAK2, 101/124 nM for MARK2/MARK3 respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

OICR19451 is a potent and selective dual NUAK1/2 and MARK2/3 inhibitor with IC50 of 12/10 nM for NUAK1/NUAK2, 101/124 nM for MARK2/MARK3 respectively.
OICR19451 showed >200-fold selectivity over MST1 (IC50=2064 nM), MST2 (IC50 = 3493 nM) and LATS1 (IC50 = 3607 nM) with reduced selectivity (45-fold) over only LATS2 (IC50 = 454 nM).
OICR19451 increases YAP phosphorylation in MDA-MB-231 breast cancer cells with EC50 of 125 nM, potently inhibit YAP/TAZ nuclear translocation, decreases expression of the YAP/TAZ target genes ANKRD1 and CTGF.
OICR19451 (30, 60 mg/kg, p.o. QD) demonstrated good tumor growth inhibition and prolongation of survival in orthotopic metastatic TNBC model, decreased YAP/TAZ protein levels.

物理化学性质&存储条件

分子量	593.09
分子式	C26H31ClF2N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((5-Chloro-2-((2-(difluoromethoxy)-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)thiophene-2-carboxamide

参考文献

1. Smil D, et al. Eur J Med Chem. 2026 Mar 31;311:118798.

OICR19451 (OICR-19451)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

OICR19451 (OICR-19451)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.