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首页-小分子抑制剂&激动剂-Others-Other Targets-OICR-403184
OICR-403184

Chemical Structure : OICR-403184

CAS No.:

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OICR-403184 (OICR403184)

货号: PC-27082Not For Human Use, Lab Use Only.

OICR-403184 is a potent, selective inhibitor of RNA-dependent protein kinase PKR with IC50 of 263 nM, shows minimal activity against related eIF2α kinases and BRAF.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OICR-403184 is a potent, selective inhibitor of RNA-dependent protein kinase PKR with IC50 of 263 nM, shows minimal activity against related eIF2α kinases and BRAF.

物理化学性质&存储条件

分子量 533.59
分子式 C24H22F3N5O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(5-(2-amino-6-methylpyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

参考文献

1. Yin J, et al. J Med Chem. 2026 Jun 22. doi: 10.1021/acs.jmedchem.5c03664.

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