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OGT 2115

Chemical Structure : OGT 2115

CAS No.: 853929-59-6

OGT 2115 (OGT2115, OGT-2115)

货号: PC-23394Not For Human Use, Lab Use Only.

OGT 2115 is a potent, specific, cell-permeable and orally active heparanase inhibitor with IC50 of 0.4 uM, inhibits the expression and activity of heparanase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

OGT 2115 is a potent, specific, cell-permeable and orally active heparanase inhibitor with IC50 of 0.4 uM, inhibits the expression and activity of heparanase.
OGT 2115 decreases mitochondrial oxygen consumption, inhibited mitochondrial complex II-III activity.
OGT 2115 dramatically reduces HSV-2 release from vaginal epithelial cells.
OGT 2115 inhibits invasion and migration of breast cancer cells through the downregulation of heparanase.

物理化学性质&存储条件

分子量 495.30
分子式 C24H16BrFN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid

参考文献

1. Courtney SM, et al. Bioorg Med Chem Lett. 2005 May 2;15(9):2295-9.

2. Li Y, et al. Int J Mol Med. 2013 May;31(5):1234-42.

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