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OGG1 inhibitor O8

Chemical Structure : OGG1 inhibitor O8

CAS No.: 350997-39-6

OGG1 inhibitor O8 (OGG1 inhibitor 08)

货号: PC-35807Not For Human Use, Lab Use Only.

OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).

物理化学性质&存储条件

分子量 261.12
分子式 C9H6Cl2N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,4-dichlorobenzo[b]thiophene-2-carbohydrazide

参考文献

1. Donley N, et al. ACS Chem Biol. 2015 Oct 16;10(10):2334-43. doi: 10.1021/acschembio.5b00452.

2. Visnes T, et al. Science. 2018 Nov 16;362(6416):834-839.

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