OF-1 |CAS:919973-83-4 Probechem Biochemicals

Chemical Structure : OF-1

CAS No.: 919973-83-4

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OF-1

货号: PC-62276Not For Human Use, Lab Use Only.

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.

规格	价格	库存
5 mg	￥880	In stock
25 mg	￥2580	In stock
50 mg	￥4480	In stock
100 mg	￥6580	In stock

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生物&药学活性

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM; displays good selectivity against other bromodomains, 39-fold selectivity over closest off-target BRD4.

物理化学性质&存储条件

分子量	440.312
分子式	C17H18BrN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

参考文献

1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.

2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

3. Meier JC, et al. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630.

OF-1

生物&药学活性

物理化学性质&存储条件

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OF-1

生物&药学活性

物理化学性质&存储条件

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