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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-ODZ10117
ODZ10117

Chemical Structure : ODZ10117

CAS No.: 1632152-27-2

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ODZ10117 (ODZ 10117)

货号: PC-47064Not For Human Use, Lab Use Only.

ODZ10117 is a small molecule inhibitor of STAT3, effectively inhibits the level of tyrosine phosphorylated STAT3 in various cancer cell lines.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ODZ10117 is a small molecule inhibitor of STAT3, effectively inhibits the level of tyrosine phosphorylated STAT3 in various cancer cell lines.
    ODZ10117 binds to the phospho-tyrosine binding pocket on the SH2 domain of STAT3 with a docking score of -6.17 kcal/mol and participated in many interactions with surrounding residues of the SH2 domain.
    ODZ10117 significantly decreased the homodimerization of STAT3, inhibited the transcriptional activity of STAT3 in a concentration-dependent manner with IC50 of 7.5 uM in in MDA-MB-231 cells.
    ODZ10117 did not significantly inhibit the JAK family of tyrosine kinases, including JAK1, JAK2, JAK3, and TYK2, in breast cancer cells and Hodgkin's lymphoma cells.
    ODZ10117 induces apoptotic cell death and decreases migration and invasion of breast cancer.
    ODZ10117 (1-10 mg/kg, 5 times a week for 23 days) suppressed tumor growth in breast cancer xenograft models, inhibits tumor growth and lung metastasis and increases survival in breast cancer xenograft model.

    物理化学性质&存储条件

    分子量 362.412
    分子式 C10H5Cl5N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(2,4-dichloro-phenoxymethyl)-5-trichloromethyl-[1,2,4]oxadiazole

    参考文献

    1. Kim BH, et al. J Clin Med. 2019 Nov 2;8(11):1847.

    2. Kim BH, et al. Cells. 2020 Mar 15;9(3):722.

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