ODM-207 |CAS:1801503-93-4 Probechem Biochemicals

Chemical Structure : ODM-207

CAS No.: 1801503-93-4

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ODM-207 (ODM207)

货号: PC-38064Not For Human Use, Lab Use Only.

ODM-207 (ODM207) is a highly potent, selective and orally active pan-BET inhibitor with potent and broad antiproliferative effects.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

ODM-207 (ODM207) is a highly potent, selective and orally active pan-BET inhibitor with potent and broad antiproliferative effects.
ODM-207 effectively inhibits the proliferation of ER+ breast cancer cell lines by inducing cell cycle arrest in G0/G1-phase.
ODM-207 suppresses the growth of ER+ patient-derived breast cancer xenograft tumors. ODM-207 was shown to synergize with palbociclib in vitro in ER+ breast cancer cell lines.
ODM-207 targeted several pathways important for cancer progression such as MYC, estrogen response and cell cycle gene signatures.
The combination of ODM-207 and CDK4/6 inhibitor palbociclib achieved greater cell proliferation inhibition than either drug alone at sub IC50 concentrations.

物理化学性质&存储条件

分子量	375.428
分子式	C22H21N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3,5-dimethylisoxazol-4-yl)-7-methoxy-3-methyl-1-(pyridin-2-ylmethyl)quinolin-2(1H)-one

参考文献

1. Ameratunga M, et al. Br J Cancer. 2020 Dec;123(12):1730-1736.

2. Sun Y, et al. Front Pharmacol. 2021 Jan 26;11:621093.

3. Mäkelä R, et al. Oncotarget. 2021 May 25;12(11):1100-1109.

ODM-207 (ODM207)

生物&药学活性

物理化学性质&存储条件

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ODM-207 (ODM207)

生物&药学活性

物理化学性质&存储条件

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