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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-ODM-203
ODM-203

Chemical Structure : ODM-203

CAS No.: 1430723-35-5

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ODM-203 (ODM203;ODM 203)

货号: PC-35715Not For Human Use, Lab Use Only.

ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
ODM-203 suppresses 9/317 additional kinases by >70% at 1 uM, 9 kinases suppressed by ODM-203 - DDR1, MAP4K4, MINK1, RET, PDGFRa and SIK2 (IC50<100 nM).
ODM-203 is a potent inhibitor of FGFR signaling and proliferation in several FGFR-dependent cell lines; ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nM) with similar potency as it inhibits proliferation in FGFR-dependent cell lines (IC50 50-150 nM).
ODM-203 inhibits FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts.

物理化学性质&存储条件

分子量 505.544
分子式 C26H21F2N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO (50.5 mg/mL）
Chemical Name/SMILES

N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide

参考文献

1. Holmström TH, et al. Mol Cancer Ther. 2018 Oct 9. pii: molcanther.0204.2018.

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